NOVEL TLR2 ANTAGONISTS
NOVEL TLR2 ANTAGONISTS
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작성자 관리자 작성일 조회546회관련링크
본문
해외/PCT 출원 : 2015.12.23
해외/PCT 등록일자 :
해외/PCT 등록번호 : PCTKR2015014202
The present invention relates to TLR2 antagonists, which are small novel molecules, and, particularly, to: 19 novel TLR2 antagonists; a pharmaceutical composition, containing the antagonists, for preventing or treating inflammatory diseases; and a TLR4 modulator, containing the antagonists. The novel TLR2 antagonists according to the present invention can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present invention can be used as a TLR4 modulator.
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