METHOD FOR POSITIONING, IN CYTOPLASM, ANTIBODY HAVING COMPLETE IMMUNOGLOBULIN FORM BY PENETRATING ANTIBODY THROUGH CELL MEMBRANE, AND USE FOR SAME
METHOD FOR POSITIONING, IN CYTOPLASM, ANTIBODY HAVING COMPLETE IMMUNOGLOBULIN FORM BY PENETRATING ANTIBODY THROUGH CELL MEMBRANE, AND USE FOR SAME
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작성자 관리자 작성일 조회550회관련링크
본문
해외/PCT 출원 : 2015.07.22
해외/PCT 등록일자 :
해외/PCT 등록번호 : PCTKR2015007626
The present invention relates to a method for positioning, in a cytoplasm, an antibody having a complete immunoglobulin form, by means of active cell penetration. In addition, the present invention relates to a light chain variable region (VL) that induces the active penetration of a cell membrane of a living cell by an antibody having a complete immunoglobulin form and the positioning of the antibody in the cytoplasm, and an antibody comprising same. Also, the present invention relates to a bioactive molecule fused to the antibody. Also, the present invention relates to a composition for preventing, treating or diagnosing cancer, comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes the light chain variable region and the antibody. The present invention also relates to a method for preparing an antibody that is made to penetrate through to the inside of a cell and positioned in the cytoplasm.
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